I will pay for the following article Sex Hormone-Binding Globulin Gene. The work is to be 18 pages with three to five sources, with in-text citations and a reference page. Although the single human SHBG gene is expressed in the testis, human transcripts of this gene are confined to testicular germ cells. This gene encodes an amino-terminally truncated SHBG isoform which accumulates in the acrosome of sperm and subsequently binds to steroids in the same way as plasma SHBG. As a result of its high affinity and selective nature towards sex steroids, the concentration of SHBG in human blood is the major determining factor of the number of free androgens and estrogens in target cells. Additionally, it is possible that SHBG in plasma within the extracellular matrix of particular tissues may affect the biological activities of sex steroids at the target cell level. SHBG can also bind to a number of pharmaceutically manufactured steroids, xenobiotics, and flavonoids. However, such interactions may have far-implicating effects in medicine environmental toxicology. In clinical medicine, these associations are exemplified in areas of hormone-replacement therapy, diagnostic imaging of cancer, and oral contraceptives (Xita & Tsatsoulis, 2010).

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