I need help creating a thesis and an outline on The Use of Beta-blockers and ACE Inhibitors or Endothelin Receptor Antagonist and ACE Inhibitors as Combination Therapy for Heart Failure. Prepare this assignment according to the guidelines found in the APA Style Guide. An abstract is required. A new paradigm was therefore taken to combining the three independent interventions in a manner that mad the presence of ACE inhibitors constant. The resulting combined therapies that were produced were ACE inhibitors and beta-blockers, ACE inhibitors, and endothelin receptors, antagonists. Different tests were conducted on patients with heart failure to find out the most preferred inclusion and exclusion criteria that work for different patients when attempting to use any of the combined therapies. This critical review showed that when used independently, the three therapies produced less effective results as compared to combined therapies, with the combination therapy applying ACE inhibitors and beta-blockers being the more effective combination therapy than ACE inhibitors and endothelin receptor antagonists.